Overview
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.8
USERS' SCORE
Good
Based on 8 Reviews
8.1
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Magnesium (as Magnesium Oxide)
250 mg
60%
Top Medical Research Studies
8
Magnesium's impact on heart health
We examined the connection between dietary magnesium and cardiovascular disease, focusing on how magnesium intake or serum levels relate to heart health. Over the last couple of decades, numerous studies have shown that low magnesium levels are associated with several heart-related issues, including high blood pressure, heart attacks, and even heart failure.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
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9
We investigated how magnesium impacts cardiovascular health, particularly its role in a condition known as arteriosclerosis. This disease can lead to serious heart complications, but recent studies revealed magnesium's potential benefits.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
Read More
8
Magnesium linked to cardiovascular health
We examined how magnesium levels in the blood could influence the risk of death from cardiovascular issues in patients with advanced chronic kidney disease (CKD). Our study tracked 1,271 individuals with CKD stages 4 and 5 over a decade, focusing on those who had not previously experienced major heart-related events.
We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.
This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.
This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
Read More
Most Useful Reviews
7.5
Improved heart health
43 people found this helpful
I have heart issues, sleep problems, and constant fatigue. This medication helps maintain bone density, regulates my heartbeat, and prevents cardiovascular disease. After the first dose, I slept soundly and felt refreshed. Irritability vanished instantly, boosting my concentration and productivity. I highly recommend it!
Read More
8
Supports heart function
3 people found this helpful
One capsule of this magnesium complex offers everything needed daily. It aids muscle function, nerve impulse transmission, and protects against cardiovascular disease. It combats fatigue and depression, and I recommend taking it with meals.
Read More
8
Eases muscle cramps
1 people found this helpful
Magnesium is vital for overall health, supporting the cardiovascular and nervous systems. It helps prevent muscle cramps when following a ketogenic diet. It aids relaxation, improves sleep, and combats fatigue due to overexertion.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.8
- All Researches
9
We investigated how magnesium impacts cardiovascular health, particularly its role in a condition known as arteriosclerosis. This disease can lead to serious heart complications, but recent studies revealed magnesium's potential benefits.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
Read More
8
Magnesium linked to cardiovascular health
We examined how magnesium levels in the blood could influence the risk of death from cardiovascular issues in patients with advanced chronic kidney disease (CKD). Our study tracked 1,271 individuals with CKD stages 4 and 5 over a decade, focusing on those who had not previously experienced major heart-related events.
We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.
This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.
This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
Read More
8
We explored the connection between dietary magnesium intake and cardiovascular disease, particularly in people living with diabetes. This study analyzed data from a large group of over 5,000 individuals who participated in the National Health and Nutrition Examination Survey over nearly two decades.
By utilizing advanced statistical methods, researchers identified key dietary factors that could predict long-term mortality risks. Notably, they found that higher intakes of dietary fiber and magnesium were associated with a decreased risk of both all-cause and cardiovascular-related deaths among people with diabetes. The analysis revealed a clear trend: as magnesium intake increased, the risk of cardiovascular mortality decreased.
The study suggests that incorporating more magnesium-rich foods could play a vital role in managing heart health for those with diabetes. By making informed dietary choices, individuals may enhance their longevity and reduce the risk of serious health complications.
By utilizing advanced statistical methods, researchers identified key dietary factors that could predict long-term mortality risks. Notably, they found that higher intakes of dietary fiber and magnesium were associated with a decreased risk of both all-cause and cardiovascular-related deaths among people with diabetes. The analysis revealed a clear trend: as magnesium intake increased, the risk of cardiovascular mortality decreased.
The study suggests that incorporating more magnesium-rich foods could play a vital role in managing heart health for those with diabetes. By making informed dietary choices, individuals may enhance their longevity and reduce the risk of serious health complications.
Read More
8
We explored the connections between magnesium (Mg), calcium (Ca), and abnormal levels of HbA1c—a key marker for blood sugar management—in adults with coronary artery disease (CAD). Our research involved a substantial group of 11,934 patients, allowing us to gain valuable insights into how these minerals impact cardiovascular health.
Our findings reveal a noteworthy association: higher serum magnesium levels appear to be linked to lower HbA1c concentrations. Specifically, patients with higher magnesium levels showed a significant decrease in the likelihood of having abnormal HbA1c readings. In contrast, calcium levels did not demonstrate a similar beneficial effect; they were not associated with abnormal HbA1c levels at all.
Interestingly, we also noted that while magnesium correlates with better fasting blood glucose outcomes, higher calcium levels were actually associated with worse results. Additionally, our analysis indicated that inflammation, as gauged by a specific blood marker, didn't mediate the relationship between magnesium and HbA1c. This suggests that magnesium might play a direct role in blood sugar regulation, separate from inflammation's influence.
Overall, our study highlights magnesium's potential importance in managing blood sugar levels among individuals with heart disease, pointing to a promising area for future research and potential dietary considerations.
Our findings reveal a noteworthy association: higher serum magnesium levels appear to be linked to lower HbA1c concentrations. Specifically, patients with higher magnesium levels showed a significant decrease in the likelihood of having abnormal HbA1c readings. In contrast, calcium levels did not demonstrate a similar beneficial effect; they were not associated with abnormal HbA1c levels at all.
Interestingly, we also noted that while magnesium correlates with better fasting blood glucose outcomes, higher calcium levels were actually associated with worse results. Additionally, our analysis indicated that inflammation, as gauged by a specific blood marker, didn't mediate the relationship between magnesium and HbA1c. This suggests that magnesium might play a direct role in blood sugar regulation, separate from inflammation's influence.
Overall, our study highlights magnesium's potential importance in managing blood sugar levels among individuals with heart disease, pointing to a promising area for future research and potential dietary considerations.
Read More
8
We explored how magnesium supplementation affects mortality rates in patients with heart failure with preserved ejection fraction (HFpEF), a subset of heart failure where treatment options are limited. The study analyzed data from the MIMIC-IV database, focusing on patients from 2008 to 2019. Using a technique called propensity score matching, we aimed to create a balanced comparison between those who received magnesium supplements and those who did not.
Our primary focus was on the 28-day all-cause mortality rate, along with secondary analyses of ICU stays, one-year mortality, and overall hospitalization duration. In total, we evaluated 1,970 patients, splitting them evenly between the magnesium and non-magnesium groups. The outcomes were striking: magnesium intake was associated with a significant reduction in mortality within the first 28 days, particularly benefiting older adults, women, and individuals with hypertension.
While magnesium supplementation showed promise in reducing mortality and also improved longer-term outcomes, we noted that it was linked to longer stays in both ICU and hospital settings. Interestingly, we found that blood urea nitrogen levels may play a role in mediating the relationship between magnesium intake and mortality, suggesting a more complex interaction at play.
This research highlights the potential of magnesium as a valuable treatment for those grappling with HFpEF, especially certain at-risk groups. As we consider these findings, further research is needed to explore magnesium's effects more thoroughly and understand its full implications for patient care.
Our primary focus was on the 28-day all-cause mortality rate, along with secondary analyses of ICU stays, one-year mortality, and overall hospitalization duration. In total, we evaluated 1,970 patients, splitting them evenly between the magnesium and non-magnesium groups. The outcomes were striking: magnesium intake was associated with a significant reduction in mortality within the first 28 days, particularly benefiting older adults, women, and individuals with hypertension.
While magnesium supplementation showed promise in reducing mortality and also improved longer-term outcomes, we noted that it was linked to longer stays in both ICU and hospital settings. Interestingly, we found that blood urea nitrogen levels may play a role in mediating the relationship between magnesium intake and mortality, suggesting a more complex interaction at play.
This research highlights the potential of magnesium as a valuable treatment for those grappling with HFpEF, especially certain at-risk groups. As we consider these findings, further research is needed to explore magnesium's effects more thoroughly and understand its full implications for patient care.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved heart health
43 people found this helpful
I have heart issues, sleep problems, and constant fatigue. This medication helps maintain bone density, regulates my heartbeat, and prevents cardiovascular disease. After the first dose, I slept soundly and felt refreshed. Irritability vanished instantly, boosting my concentration and productivity. I highly recommend it!
Read More
8
Supports heart function
3 people found this helpful
One capsule of this magnesium complex offers everything needed daily. It aids muscle function, nerve impulse transmission, and protects against cardiovascular disease. It combats fatigue and depression, and I recommend taking it with meals.
Read More
8
Eases muscle cramps
1 people found this helpful
Magnesium is vital for overall health, supporting the cardiovascular and nervous systems. It helps prevent muscle cramps when following a ketogenic diet. It aids relaxation, improves sleep, and combats fatigue due to overexertion.
Read More
7.5
Fights fatigue
1 people found this helpful
Magnesium is an essential mineral, primarily found in bones and teeth. It plays a vital role in transmitting neuromuscular impulses. A deficiency can lead to increased fatigue. It combats seizures and protects the cardiovascular system. I find it extremely helpful and consume it regularly.
Read More
7.5
Calms nervous system
Magnesium is crucial for good health, supporting the cardiovascular and nervous systems. Since taking it, my nervous system has calmed down, and I only take one tablet daily. I highly recommend this mineral based on its beneficial effects.
Read More
Frequently Asked Questions
7.5
Improved heart health
43 people found this helpful
I have heart issues, sleep problems, and constant fatigue. This medication helps maintain bone density, regulates my heartbeat, and prevents cardiovascular disease. After the first dose, I slept soundly and felt refreshed. Irritability vanished instantly, boosting my concentration and productivity. I highly recommend it!
7.5
Calms nervous system
Magnesium is crucial for good health, supporting the cardiovascular and nervous systems. Since taking it, my nervous system has calmed down, and I only take one tablet daily. I highly recommend this mineral based on its beneficial effects.
8
Helpful for heart
23 people found this helpful
Magnesium is essential for daily body functions. It regulates heart rhythms, normalises blood pressure, and lowers the risk of cardiovascular disease. I take one tablet at night, which relaxes me and alleviates headaches induced by my dystonia. My friend noticed its benefits as well, appreciating its effectiveness.
7.5
Enhances sleep quality
Magnesium improves the immune and cardiovascular systems. It helps alleviate cramps, enhances sleep, and calms nerves. I recommend taking it in the evening after a meal for the best effect.
8
Supports heart function
3 people found this helpful
One capsule of this magnesium complex offers everything needed daily. It aids muscle function, nerve impulse transmission, and protects against cardiovascular disease. It combats fatigue and depression, and I recommend taking it with meals.
8
Eases muscle cramps
1 people found this helpful
Magnesium is vital for overall health, supporting the cardiovascular and nervous systems. It helps prevent muscle cramps when following a ketogenic diet. It aids relaxation, improves sleep, and combats fatigue due to overexertion.
7.5
Fights fatigue
1 people found this helpful
Magnesium is an essential mineral, primarily found in bones and teeth. It plays a vital role in transmitting neuromuscular impulses. A deficiency can lead to increased fatigue. It combats seizures and protects the cardiovascular system. I find it extremely helpful and consume it regularly.
8
Magnesium linked to cardiovascular health
We examined how magnesium levels in the blood could influence the risk of death from cardiovascular issues in patients with advanced chronic kidney disease (CKD). Our study tracked 1,271 individuals with CKD stages 4 and 5 over a decade, focusing on those who had not previously experienced major heart-related events.
We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.
This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.
This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
8
We explored the connection between dietary magnesium intake and cardiovascular disease, particularly in people living with diabetes. This study analyzed data from a large group of over 5,000 individuals who participated in the National Health and Nutrition Examination Survey over nearly two decades.
By utilizing advanced statistical methods, researchers identified key dietary factors that could predict long-term mortality risks. Notably, they found that higher intakes of dietary fiber and magnesium were associated with a decreased risk of both all-cause and cardiovascular-related deaths among people with diabetes. The analysis revealed a clear trend: as magnesium intake increased, the risk of cardiovascular mortality decreased.
The study suggests that incorporating more magnesium-rich foods could play a vital role in managing heart health for those with diabetes. By making informed dietary choices, individuals may enhance their longevity and reduce the risk of serious health complications.
By utilizing advanced statistical methods, researchers identified key dietary factors that could predict long-term mortality risks. Notably, they found that higher intakes of dietary fiber and magnesium were associated with a decreased risk of both all-cause and cardiovascular-related deaths among people with diabetes. The analysis revealed a clear trend: as magnesium intake increased, the risk of cardiovascular mortality decreased.
The study suggests that incorporating more magnesium-rich foods could play a vital role in managing heart health for those with diabetes. By making informed dietary choices, individuals may enhance their longevity and reduce the risk of serious health complications.
8
We explored how magnesium supplementation affects mortality rates in patients with heart failure with preserved ejection fraction (HFpEF), a subset of heart failure where treatment options are limited. The study analyzed data from the MIMIC-IV database, focusing on patients from 2008 to 2019. Using a technique called propensity score matching, we aimed to create a balanced comparison between those who received magnesium supplements and those who did not.
Our primary focus was on the 28-day all-cause mortality rate, along with secondary analyses of ICU stays, one-year mortality, and overall hospitalization duration. In total, we evaluated 1,970 patients, splitting them evenly between the magnesium and non-magnesium groups. The outcomes were striking: magnesium intake was associated with a significant reduction in mortality within the first 28 days, particularly benefiting older adults, women, and individuals with hypertension.
While magnesium supplementation showed promise in reducing mortality and also improved longer-term outcomes, we noted that it was linked to longer stays in both ICU and hospital settings. Interestingly, we found that blood urea nitrogen levels may play a role in mediating the relationship between magnesium intake and mortality, suggesting a more complex interaction at play.
This research highlights the potential of magnesium as a valuable treatment for those grappling with HFpEF, especially certain at-risk groups. As we consider these findings, further research is needed to explore magnesium's effects more thoroughly and understand its full implications for patient care.
Our primary focus was on the 28-day all-cause mortality rate, along with secondary analyses of ICU stays, one-year mortality, and overall hospitalization duration. In total, we evaluated 1,970 patients, splitting them evenly between the magnesium and non-magnesium groups. The outcomes were striking: magnesium intake was associated with a significant reduction in mortality within the first 28 days, particularly benefiting older adults, women, and individuals with hypertension.
While magnesium supplementation showed promise in reducing mortality and also improved longer-term outcomes, we noted that it was linked to longer stays in both ICU and hospital settings. Interestingly, we found that blood urea nitrogen levels may play a role in mediating the relationship between magnesium intake and mortality, suggesting a more complex interaction at play.
This research highlights the potential of magnesium as a valuable treatment for those grappling with HFpEF, especially certain at-risk groups. As we consider these findings, further research is needed to explore magnesium's effects more thoroughly and understand its full implications for patient care.
References
- Yu H, Zhou C, Yang S, Yu J, Zhang X, et al. Mitigation of arteriosclerosis through transcriptional regulation of ferroptosis and lipid metabolism by magnesium. Biomaterials. 2025;319:123135. doi:10.1016/j.biomaterials.2025.123135
- Moyano-Peregrin C, Rodelo-Haad C, Martín-Malo A, Muñoz-Castañeda JR, Ojeda R, et al. Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5. Clin Kidney J. 2025;18:sfae390. doi:10.1093/ckj/sfae390
- Wang F, Mao Y, Sun J, Yang J, Xiao L, et al. Models based on dietary nutrients predicting all-cause and cardiovascular mortality in people with diabetes. Sci Rep. 2025;15:4600. doi:10.1038/s41598-025-88480-9
- Dong H, Lu N, Wang J, Hu P. Serum magnesium, not calcium, is inversely associated with abnormal HbA1c concentrations in adults with coronary artery disease. Asia Pac J Clin Nutr. 2025;34:104. doi:10.6133/apjcn.202502_34(1).0010
- Song L, Ying J, Li M, Ying L, Zhao C. Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF. Sci Rep. 2025;15:1944. doi:10.1038/s41598-025-85931-1
- Nielsen FH. The Role of Dietary Magnesium in Cardiovascular Disease. Nutrients. 2024;16. doi:10.3390/nu16234223
- Sun L, Du J. Magnesium status, serum vitamin D concentration and mortality among congestive heart failure patients: a cohort study from NHANES 2007-2018. Magnes Res. 2024;37:61. doi:10.1684/mrh.2024.0528
- Urbanowicz T, Hanć A, Frąckowiak J, Piecek J, Spasenenko I, et al. The Hypothesis of Trace Elements Involvement in the Coronary Arteries Atherosclerotic Plaques' Location. J Clin Med. 2024;13. doi:10.3390/jcm13226933
- Cheng Y, Zullo AR, Yin Y, Shao Y, Liu S, et al. Nonprescription Magnesium Supplement Use and Risk of Heart Failure in Patients With Diabetes: A Target Trial Emulation. J Am Heart Assoc. 2025;14:e038870. doi:10.1161/JAHA.124.038870
- Shahsavani Z, Masoumi SJ, Barati-Boldaji R, Shamshirgardi E, Kafipour R, et al. Dietary Calcium to Magnesium Ratio and Risk of Cardiovascular Diseases. Biol Trace Elem Res. 2025. doi:10.1007/s12011-025-04587-0
- Pariona-Vargas F, Mun KT, Lo EH, Starkman S, Sanossian N, et al. Is there diurnal variation in neuroprotective and thrombolytic therapy effect upon acute cerebral ischemia outcome?. J Stroke Cerebrovasc Dis. 2025;34:108278. doi:10.1016/j.jstrokecerebrovasdis.2025.108278
- Amer SA, Abo-Elnour DE, Abbas A, Abdelrahman AS, Hamdy HM, et al. Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2025;25:89. doi:10.1186/s12906-025-04809-x
